mock-require is a powerful Node.js module for mocking dependencies in require() calls during testing. It enables you to replace specific modules with mocks, stubs, or spies, isolating tested code and controlling dependencies. It works without modifying file paths or dependency graphs. It simplifies unit testing by enabling you to simulate different scenarios and verify interactions with dependencies, even when they're deeply nested within the module hierarchy. It enhances the reliability and predictability of your tests.