ts-jest is a popular TypeScript preprocessor for Jest, enabling seamless testing of TypeScript code. It compiles TypeScript files on the fly, allowing Jest to understand and execute tests written in TypeScript. This eliminates the need for manual compilation before testing, streamlining the development workflow. ts-jest simplifies configuration, offers excellent performance through caching, and supports various TypeScript features. It's a must-have tool for any project using Jest with TypeScript, enhancing developer productivity and ensuring code quality.